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ACLOPRAZ

Biotrex Pharma Private Limited > ACLOPRAZ

ACLOPRAZ

				
					Composition: Aceclofenac (200mg SR) + Rabeprazole (20mg)

Aceclofenac is a phenylacetic acid derivative that inhibits cyclooxygenase (COX-1 and COX-2) enzymes, halting the production of inflammatory prostaglandins. The Sustained Release (SR) mechanism ensures a steady plasma concentration over 24 hours. Rabeprazole is a substituted benzimidazole (PPI) that irreversibly inhibits the H+/K+ ATPase pump in gastric parietal cells, suppressing acid production to prevent NSAID-induced ulcers.

Extended Pain Control: Single daily dose management for chronic inflammatory conditions.
Gastric Shielding: Proactively prevents the "gastritis" and "peptic ulcers" typically associated with long-term painkiller use.
Mobility: Reduces morning stiffness and joint swelling, allowing for improved physical therapy outcomes and daily activity.

Generally Prescribed for Following:

  • Chronic Arthritis: Rheumatoid arthritis, Osteoarthritis, and Ankylosing spondylitis.
  • Severe Pain: Acute gout, lower back pain, and post-traumatic inflammation.
  • Post-Surgical: Management of pain and swelling following orthopedic or dental surgery.

Potential Side Effects and Adverse Reactions:

Digestive: Dyspepsia (indigestion), flatulence, and occasional diarrhea.
Systemic: Dizziness, headache, and rare elevations in liver transaminases.
Long-term PPI use: May slightly decrease the absorption of Vitamin B12 and Magnesium with very prolonged use.

General Advisories and Critical Avoidances:

Alcohol: HIGH RISK. Combining NSAIDs with alcohol increases the risk of gastric perforation and occult GI bleeding.
Pregnancy: Contraindicated in the third trimester (risk of premature closure of ductus arteriosus).
Avoid: Taking with other NSAIDs (like Ibuprofen or Aspirin) as it increases toxicity.

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