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PREGATREX-M

				
					Composition: Methylcobalamin (1500mcg) + Pregabalin (75mg)

				
			

A dual-action neurotrophic and analgesic agent. Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of neurotransmitters like glutamate and substance P. Methylcobalamin acts as a coenzyme in the synthesis of methionine from homocysteine, which is essential for the formation of the myelin sheath that protects nerve fibers.

Nerve Regeneration: Actively promotes the repair of damaged neurons by facilitating protein synthesis and myelin sheath formation.
Rapid Pain Relief: Provides significant reduction in "burning," "electric shock," and "stabbing" sensations.
Quality of Life: Reduces sleep interference and anxiety-related symptoms caused by chronic, debilitating nerve pain.

Generally Prescribed for Following:

Potential Side Effects and Adverse Reactions:

CNS Effects: Significant dizziness, somnolence (extreme sleepiness), and ataxia (loss of coordination).
Visual: Blurred or double vision (diplopia). Metabolic: Increased appetite leading to weight gain and peripheral edema (fluid retention in limbs).
Psychiatric: Occasionally may cause mood changes or confusion in elderly patients.

General Advisories and Critical Avoidances:

Alcohol: STRICT AVOIDANCE. Alcohol synergistically increases the sedative effects of Pregabalin, which can lead to severe respiratory depression.
Lactation: Not recommended unless vital; Pregabalin passes into breast milk.
Avoid: Sudden discontinuation (must taper off to avoid rebound insomnia or anxiety).

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